谢维

	谢 维	教授、博士生导师 “发育与疾病相关基因”教育部重点实验室 主任
	电话：	025-83790970
	E-mail：	wei.xie@seu.edu.cn
	Labweb：
	办公地点：	南京市四牌楼2号，李文正楼北221

个人简介：

   1981年7月参加工作，1991年6月毕业于南京铁道医学院微生物学与免疫学专业，获硕士学位；1995年10月毕业于南京大学生物化学与分子生物学系，获博士学位。1997年1月至1998年12月在美国罗切斯特大学医学中心作博士后；1999年5月至2001年8月在加拿大多伦多大学附属多伦多病童医院博士后、访问学者。2001年9月作为教育部“CJ学者奖励计划”特聘教授，受聘为必威betway中文官网基础医学院遗传学研究中心主任，博士生导师；2003年获准建设“发育与疾病相关基因”教育部重点实验室，任主任；2004年4月至2009年11月任必威betway中文官网基础医学院院长，2009年12月至2019年12月，任必威西汉姆联官网院长。先后获得国家自然科学基金（面上、重点）、国家杰出青年科学基金、美国NIH基金（RO3）、国家“973”重大基础研究项目等资助。

研究方向：突触发育调控与认知疾病机制

   大脑通过约10¹⁵个突触连接而成的巨大通讯网络来进行信息处理、行使功能。突触通过自身的可塑性，传递、转变和完善信号。突触细胞粘附因子，通过连接突触前、后细胞，调节突触传递信号，并且通过形成特异性的突触功能来决定神经网络的特性。家系分析发现，人类突触细胞粘附因子基因发生突变与孤独症、精神分裂症等关联；基因组水平研究显示，包括孤独症、精神分裂症等多种认知性疾病，均存在编码突触分子，如Caherins、Protocadherins、L1CAM、Neuroligin、Neurexin、CNTNAP2和Contactins等的基因异常，但其致病机制不清。本研究组以神经元表面蛋白分子为研究对象，应用综合研究手段，结合模式生物，探索突触发生、成熟、环路形成以及在学习记忆等高级神经活动与行为中的作用，探讨其在遗传和表观遗传水平上的调控机制，为阐明其在相关的认知障碍与疾病中的作用奠定基础。

本课题组日常负责人联系方式：

吕卉卉：025-83790976 

近期代表性论文：

1.    Dandan Lv, An Liu*, Ziyue Yi, Mingdao Mu, Miao Wu, Xingcan Li, Kun Cao, Ruining Liu, Zhengping Jia, Junhai Han, Wei Xie*. Neuroligin 1 Regulates Autistic-Like Repetitive Behavior through Modulating the Activity of Striatal D2 Receptor-Expressing Medium Spiny Neurons. Adv Science (Weinh). 2025 Feb;12(5):e2410728.

2.    Peng Xie, Juan Shen, Yi Yang, Xinrui Wang, Wei Liu, Hailong Cao, Yanying Zheng, Chen Wu, Guangyao Mao, Linjin Chen, Jingjing He, Weiheng Zheng, Zepu Yang, Xiao Zhang, Xu Jiang, Xianfa Yang, Ke Fang, Zhao Zhang, Xin Xue, Xueting Chen, Chaoyi Wang, Xing Liu, Ling Liu, Xuebiao Yao, Naihe Jing, Wei Xie, Jin Liu, Hua Cao, Zhuojuan Luo*, Xiaodong Fang*, Chengqi Lin*. Digital reconstruction of full embryos during early mouse organogenesis. Cell, 2025, 188, 1-19.

3.    Shiqi Zhu, Peng Xie, Yi Yang, Yan Wang, Chuanxin Zhang, Yu Zhang, Shuhan Si, Jin Zhang, Jingjing He, Hao Si, Ke Fang, Binbin Ma, Xu Jiang, Lindi Huang, Jiamin Li, Tian Min, Beihong Zheng, Lincui Da, Dianliang Lin, Kun Gao, Yuanyuan Li, Mingtao Huang, Fengchang Qiao, Haiqin Huo, Haoyang Feng, Han Zhao, Zijiang Chen, Zhengfeng Xu, Jing Xie, Hua Cao, Jin Liu, Xuebiao Yao, Wei Xie, Yan Sun, Keliang Wu, Bo Xiong, Ping Hu*, Zhuojuan Luo*, Chengqi Lin*. Maternal ELL3 loss-of-function leads to oocyte aneuploidy and early miscarriage. Nat Struct Mol Biol. 2025 Feb;32(2):381-392.

4.    Yu Zhao, Junhua Geng*, Zhu Meng, Yichen Sun, Mengzhu Ou, Lizhong Xu, Moyi Li, Guangming Gan, Menglong Rui, Junhai Han, Wei Xie*. Neurexin facilitates glycosylation of Dystroglycan to sustain muscle architecture and function in Drosophila. Commun Biol. 2024, Nov. 9; 7:1481.

5.    Rui Dang, An Liu*, Yu Zhou, Xingcan Li, Miao Wu,Kun Cao,Yanghong Meng, Haiwang Zhang, Guangming Gan, Wei Xie* & Zhengping Jia*. Astrocytic neuroligin 3 regulates social memory and synaptic plasticity through adenosine signaling in male mice. Nat Commun 2024, 15, 8639.

6.    Mingdao Mu*, Haoyu Sun, Shuyan Geng, Tianxiang Xu, Chuanyao Sun, Zixu Zhang, Sibie Meng, Moyi Li, An Liu, Zhiyuan Yang and Wei Xie*. Neurexin-3 in the paraventricular nucleus of the hypothalamus regulates body weight and glucose homeostasis independently of food intake. Mol Brain, 2024, 17:49.

7.    Haiyan Sun*, Yu Shen, Pengtao Ni, Xin Liu, Yan Li, Zhentong Qiu, Jiawen Su, Yihan Wang, Miao Wu, Xiangxi Kong, Jun-Li Cao*, Wei Xie*, and Shuming An*. Autism-associated neuroligin-3 deficiency in medial septum causes social deficits and sleep loss in mice. J Clin Invest. 2024 Jul 25:e176770.

8.    Siqi Peng, Xiuqi Yang, Sibie Meng, Fuyuan Liu, Yaochen Lv, Huiquan Yang, Youyong Kong, Wei Xie, Moyi Li*. Dual circuits from hippocampus facilitate naive social 2 transfer of observational fear. Cell Reports, 2024 May 27;43(6):114277.

9.    Qiaoyun Ren, Susu Wang, Junru Li, Kun Cao, Mei Zhuang, Miao Wu, Junhua Geng, Zhengping Jia, Wei Xie, An Liu*. Novel social stimulation ameliorates memory deficit in Alzheimer's disease model through activating α-secretase. J Neurosci. 2024 Feb 28:e1689232024. (This Week in The Journal)

10.   Siyan Meng, Xiaoxu Liu, Shiqi Zhu, Peng Xie, Haitong Fang, Qingyun Pan, Ke Fang, Fanfan Li, Jin Zhang, Zhuanzhuan Che, Quanyong Zhang, Guangyao Mao, Yan Wang, Ping Hu, Kai Chen, Fei Sun, Wei Xie, Zhuojuan Luo*, Chengqi Lin*. Young LINE-1 transposon 5' UTRs marked by elongation factor ELL3 function as enhancers to regulate naïve pluripotency in embryonic stem cells. Nat Cell Biol. 2023 Sep;25(9):1319-1331.

11.   Yichen Sun, Moyi Li*, Junhua Geng, Sibie Meng, Renjun Tu, Yan Zhuang, Mingkuan Sun, Menglong Rui, Mengzhu Ou，Guangling Xing, Travis K Johnson, Wei Xie*. Neuroligin 2 Governs Synaptic Morphology and Function Through RACK1-Cofilin Signaling in Drosophila. Commun Biol. 2023 Oct 18;6(1):1056.

12.   Xiaofeng Han, Shuxia Guo, Nan Ji, Tian Li, Jian Liu, Xiangqiao Ye, Yi Wang, Zhixi Yun, Feng Xiong, Jing Rong, Di Liu, Hui Ma, Yujin Wang, Yue Huang, Peng Zhang, Wenhao Wu, Liya Ding, Wei Xie, Lijuan Liu, Liwei Zhang*, Hanchuan Peng*. Whole Human-Brain Mapping of Single Cortical Neurons for Profiling Morphological Diversity and Stereotypy. Science Adv, 2023, 9(41): eadf3771.

13.   Rui Dang, Yu Zhou, Yue Zhang, Die Liu, Miao Wu, An Liu, Zhengping Jia* & Wei Xie*. Regulation of Social Memory by Lateral Entorhinal Cortical Projection to Dorsal Hippocampal CA2. Neurosci Bull, 2022 https://doi.org/10.1007/ s12264-021-00813-6.

14.   Hanchuan Peng*, Peng Xie,#, Lijuan Liu#, Yimin Wang, Lei Qu, Hui Gong, Xiuli Kuang, Shengdian Jiang, Anan Li, Zongcai Ruan, Liya Ding, Mengya Chen, Tanya L. Daigle, Zhangcan Ding, Yanjun Duan, Aaron Feiner, Ping He, Chris Hill, Karla E. Hirokawa, Guodong Hong, Lei Huang, Sara Kebede, Hsien-Chi Kuo, Rachael Larsen, Phil Lesnar, Longfei Li, Qi Li, Xiangning Li, Yaoyao Li, Yuanyuan Li, An Liu, et al, Yefeng Zheng, Zhongze Gu, Wei Xie, Christof Koch, Qingming Luo, Julie A. Harris, Yun Wang, Hongkui Zeng*. Complete whole-brain single neuron reconstruction reveals morphological diversity in molecularly defined striatal, thalamic, cortical and claustral neuron types. Nature, 2021, 598:174-181.

15.   Yuqian Shen, Zi Chao Zhang, Shanshan Cheng, An Liu, Jian Zuo, Shuting Xia, Xian Liu, Wenhua Liu, Zhengping Jia, Wei Xie, Junhai Han*. PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation. Mol Cell, 2021, 81:1425-1438.

16.   Wei Xie*, Cheng-Qi Lin, Jian Li, Mo-Yi Li. Decoding brain encoded by genome. Yi Chuan (Hereditas Beijing), 2021 May 20;43(5):393-396.

17.   Moyi Li*, Yan Zhuang, Ranjan Batra, James D. Thomas, Mao Li, Curtis A Nutter, Marina M. Scotti, Helmut A Carter, Zhan Jun Wang, Xu Sheng Huang, Chuan Qiang Pu, Maurice S. Swanson, Wei Xie*. HNRNPA1-induced spliceopathy in a transgenic mouse model of myotonic dystrophy. Proc Natl Acad Sci U S A. 2020,117(10): 5472-5477.

18.   Xuechen Zhou, Rui Hao, Chen Chen, Zhipeng Su, Linhong Zhao, Zhuojuan Luo, Wei Xie*. Rapid Delivery of Nanobodies/ VHHs into Living Cells via Expressing In Vitro-Transcribed mRNA. Mol Therapy - Methods & Clinical Development, 2020, 17:401-408.

19.   Guanglin Xing, Moyi Li, Menglong Rui, Nana Tao, Yan Zhuang, Huihui Lv, Junhai Han, Zhengping Jia*, and Wei Xie*. Neuroligin 1 Regulates Postsynaptic Actin Cytoskeleton via WAVE Regulatory Complex in Drosophila Neuromuscular Junction, eLife, 2018, DOI: 10.7554/eLife.30457.

20.   Zikai Zhou, An Liu, Shuting Xia, Celeste Leung, Junxia Qi, Yanghong Meng, Wei Xie, Pojeong Park, Graham L. Collingridge*, Zhengping Jia*. The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning. Nat Neurosci, 2018, 21(1):50-62.

21.   Jun Wu, Yao Tian, Guanglin Xing, Nana Tao, Huihui Lv, Junhai Han, Chengqi Lin and Wei Xie*. Proteolytic Maturation of Drosophila Neuroligin 3 by Tumor Necrosis Factor α-converting Enzyme in the Nervous System. BBA-General, 2018, 1862(3):440-450.

22.   Xinwang Zhang, Menglong Rui, Guangming Gan, Cong Huang, Jukang Yi, Huihui Lv, Junhai Han, and Wei Xie*. Neuroligin 4 regulates synaptic growth via the bone morphogenetic protein (BMP) signaling pathway at the Drosophila neuromuscular junction. J Biol Chem, 2017, 292(44):17991-18005.

23.   Menglong Rui, Jinjun Qian, Lijuan Liu, Yihan Cai, Huihui Lv, Junhai Han, Zhengping Jia and Wei Xie*. The neuronal protein neurexin directly interacts with the Scribble-Pix complex to stimulate F-actin assembly for presynaptic vesicle clustering. J Biol Chem, 2017, 292(35):14334-14348.

24.   Renjun Tu, Jinjun Qian, Menglong Rui, Nana Tao, Mingkuan Sun, Yan Zhuang, Huihui Lv, Junhai Han, Moyi Li, Wei Xie*. Proteolytic cleavage is required for Neuroligin 2 maturation and function in Drosophila. JMCB, 2017, 9(3):231-242.

25.   Lina Liu, Yao Tian, Xiaoyan Zhang, Xinwang Zhang, Tao Li, Wei Xie, and Junhai Han*. Neurexin Restricts Axonal Branching in Columns by Promoting Ephrin Clustering. Deve Cell, 2017, 41:94-106.  (Cover Story)

26.   Yan Wang, Yang Shen, Qian Yang, Qian Dai, Yue Zhang, Xin Wang, Wei Xie, Zhuojuan Luo*, Chengqi Lin*. A permissive chromatin state regulated by ZFP281-AFF3 in controlling the imprinted Meg3 polycistron. Nucleic Acids Res, 2017, 45(3):1177-1185.

27.   Shuting Xia, Zikai Zhou, Celeste Leung, Yuehua Zhu, Xingxiu Pan, Maria Morena, Matthew N. Hill*, Wei Xie*, and Zhengping Jia*. p21-Activated Kinase 1 Restricts Tonic Endocannabinoid Signaling in the Hippocampus. eLife, 2016, 5:e14653.

28.   An Liu, Zikai Zhou, Rui Dang, Guiqing He, Celeste Leung, Daniel Pak, Zhengping Jia*, and Wei Xie*. Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin mediated actin reorganization. J Cell Biol, 2016, 212:449-463. (Cover Story, w/COMMENTARY)

29.   Tao Li, Yao Tan, Qian Li, Huiying Chen, Huihui Lv, Wei Xie, and Junhai Han*. Neurexin/NSF interaction regulates short-term synaptic depression. J Biol Chem 2015, 290(29):17656-67. (Papers of the Week, Cover Story, 2015 Best of Winner)

30.   Xingxiu Pan, Xinxia Chang, Celeste Leung, Zikai Zhou, Feng Cao, Wei Xie*, Zhengping Jia*. PAK1 regulates cortical development via promoting neuronal migration and progenitor cell proliferation. Mol Brain, 2015, 8:36.

31.   Guanglin Xing, Guangming Gan, Dandan Chen, Mingkuan Sun, Jukang Yi, Huihui Lv, Junhai Han, Wei Xie*. Drosophila Neuroligin3 Regulates Neuromuscular Junction Development and Synaptic Differentiation. J Biol Chem, 2014, 289(46): 31867-31877. (Paper of the Week)

32.   Yi Li, Ziaki Zhou, Xinwang Zhang, Huawei Tong, Peipei Li, Zi chao Zhang, Zhengping Jia, Wei Xie* and Junhai Han*. Drosophila Neuroligin 4 regulates sleep through modulating GABA transmission. J Neurosci, 2013, 33:15545-15554.

33.   Yao Tian, Yi Li, Mingkuan Sun, Wen Hu, Didi Wan, Jing Li, Junhai Han* and Wei Xie*. Neurexin Regulates Visual Function via Mediating Retinoid Transport to Promote Rhodopsin Maturation. Neuron, 2013, 140:413-422.

34.   SUN MingKuan*, XIE Wei*. Cell Adhesion Molecules in Drosophila Synapse Development and Function. Sci China Life Sci, 2012, 55(1):20-26.

35.   David Knight, Wei Xie and Gabrielle Boulianne*. Neurexins and Neuroligins: Recent Insights from Invertebrates. Mol Neurobiol, 2011, 44(3):426-440.

36.   Mingkuan Sun, Guanglin Xing, Liudi Yuan, Guangming Gan, David Knight, Sheila Irene With, Cui He, Junhai Han, Xiankun Zeng, Ming Fang, Gabrielle L. Boulianne*, Wei Xie*. Neuroligin2 Is Required for Synapse Development and Function at the Drosophila Neuromuscular Junction. J Neurosci, 2011, 31(2):687-699. (This Week in The Journal)

37.   Mingkuan Sun, Lijuan Liu Xiankun Zeng, Li Liu, Ming fang, Wei Xie*. Genetic Interaction between Neurexin and CAKI/CMG Is Important for the Synaptic Function in Drosophila Neuromuscular Junction. Neurosci Res, 2009, 64:362-71.

38.   Xiankun Zeng, Mingkuan Sun, Li Liu, Fading Chen, Liuchan Wei, Wei Xie*. Neurexin-1 is required for synapse formation and larvae associative learning in Drosophila. FEBS Lett, 2007,581:2509-2516.