汪晶晶

发布者:何亦橦发布时间:2024-09-02浏览次数:5100

汪晶晶教授/博导

 E-mail: jingjing.wang@seu.edu.cn

办公地点:必威betway中文官网江北校区汇川楼B301




个人简介:

2009年本科毕业于安徽大学,2016年在中国科学院微生物研究所获得博士学位。2016-2023先后在美国科罗拉多大学(2016-2020)、美国西北大学菲恩伯格医学院(2021-2023)从事博士后研究。2023-2024任美国西北大学菲恩伯格医学院副研究员。2024年6月入职必威betway中文官网。


研究方向:非编码RNA调控干细胞命运控制皮肤极其附属器发育与再生

皮肤是人体最外层组织。除表皮和真皮外,皮肤还拥有包括毛囊、皮脂腺等附属器。皮肤及其附属器的发育、稳态维持与再生依赖于皮肤中各类干细胞命运的正常调控。皮肤干细胞命运调控异常会导致多种皮肤病如遗传性皮肤病、脱发、黑色素瘤等的发生。

本课题组运用分子遗传学、细胞生物学、生物化学、转录组学、活体动物细胞影像学等多学科研究方法,以小鼠皮肤为模型,从miRNA-靶标基因网络入手,开展调控干细胞命运控制皮肤及其附属器发育、稳态维持与再生的功能和机制研究,同时探究机械力学特性改变在脱发、皮肤疾病发病过程中的作用。


代表性论文:

1. Jingjing Wang, Chaoyu Fu, Sophie Chang, Christopher Stephens, Haimin Li, Dongmei Wang,Yuheng Fu, Kathleen J. Green, Jie Yan and Rui Yi. PIEZO1-mediated calcium signaling reinforces mechanical properties of hair follicle stem cells to promote quiescence. Science Advances,Vol 11, Issue 22, 2025.

2. Jingjing Wang, Yuheng Fu, Joshua A. Broussard, Ritusree Biswas, Avinanda Banerjee, Zhihai   Zhao, Wenmao Huang, Dongmei Wang, Glen Bjerke, Srikala Raghavan, Jie Yan, Kathleen J. Green & Rui Yi. MicroRNA-205 promotes hair regeneration by modulating mechanical properties of hair follicle stem cells. Proceedings of the National Academy of Sciences of the United States of America, 120 (22) e2220635120

3. Chi Zhang, Dongmei Wang, Jingjing Wang, Li Wang, Wenli Qiu, Tsutomu Kume, Robin Dowell & Rui Yi. Escape of hair follicle stem cells causes stem cell exhaustion during aging. Nature Aging. 1, 889–903 (2021).

4. Jingjing Wang, Jerome E. Lee, Kent Riemondy, Yang Yu, Steven M. Marquez, Eric C. Lai & Rui Yi. XPO5 promotes primary miRNA processing independently of RanGTP. Nature Communications 11, 1845 (2020).

5. Chen Cui#, Jingjing Wang#, Jian-Hua Zhao#, Yuan-Yuan Fang, Xiang-Feng He, Hui-Shan Guo, & Cheng-Guo Duan. A Brassica miRNA Regulates Plant Growth and Immunity through Distinct Modes of Action. Molecular Plant. 2020 Feb 3;13(2):231-245.  

6. Jingjing Wang and Hui-Shan Guo. Cleavage of INDOLE-3-ACETIC ACID INDUCIBLE28 mRNA by microRNA847 upregulates Auxin signaling to modulate cell proliferation and lateral organ growth in Arabidopsis. The Plant Cell (online, Vol. 27: 574–590, 2015).