李默怡 副教授、博士生导师
Email: moyili@seu.edu.cn
办公地点：江北校区汇川楼A405
个人简介：
1996年9月— 2000年6月 学士，微生物专业，华中农业大学
2000年9月— 2003年6月 硕士，生化工程专业，华中科技大学
2003年8月— 2008年5月 博士，植物病理专业，佛罗里达大学
2009年1月 — 2013年7月 博士后，佛罗里达大学
2014年1月 — 2016年2月 博士后，必威西汉姆联官网
2016年2月— 2019年11月 副研究员，必威西汉姆联官网
2019年12月至今 副研究员，必威西汉姆联官网
研究方向：
1. 神经发育与退行性疾病的分子机理
2. 社交障碍及社交行为相关环路的调控机制
近期代表性论文：
* co-first author; # corresponding author
1. Peng S*, Li M*#, Yang X, Xie W. The neural basis of affective empathy: What is known from rodents. Neuropharmacology. 2025 May 15;269:110347. doi: 10.1016/j.neuropharm.2025.110347. Epub 2025 Feb 4.
2. Peng S, Yang X, Meng S, Liu F, Lv Y, Yang H, Kong Y, Xie W, Li M#. Dual circuits originating from the ventral hippocampus independently facilitate affective empathy. Cell Rep. 2024 Jun 25;43(6):114277. doi: 10.1016/j.celrep.2024.114277.
3. Sun Y, Li M#, Geng J, Meng S, Tu R, Zhuang Y, Sun M, Rui M, Ou M, Xing G, Johnson TK, Xie W#. Neuroligin 2 governs synaptic morphology and function through RACK1-cofilin signaling in Drosophila. Commun Biol. 2023 Oct 18;6(1):1056. doi: 10.1038/s42003-023-05428-3.
4. Peng S, Gu W, Zhu W, Zhuang Y, Yang X, Lv Y, Meng S,Xie W, Li M#. A new AAV tool for highly preferentially targeting hippocampal CA2. (2023) Mol Brain. Jun 11;16(1):50. doi: 10.1186/s13041-023-01038-6.
5. Li M*#, Zhuang Y*, Batra R, Thomas JD, Li M, Nutter CA, Scotti MM, Carter HA, Wang ZJ, Huang XS, Pu CQ, Swanson MS, Xie W#. HNRNPA1-induced spliceopathy in a transgenic mouse model of myotonic dystrophy. (2020) Proc. Natl. Acad. Sci. U.S.A. 117(10):5472-5477.
6. Xing G*, Li M*, Sun Y, Rui M, Zhuang Y, Lv H, Han J, Jia Z, Xie W. Neurexin-Neuroligin 1 regulates synaptic morphology and function via the WAVE regulatory complex in Drosophila neuromuscular junction. (2018) eLife;7: e30457
7. Batra R, Charizanis K, Manchanda M, Mohan A, Li M, Finn D J, Goodwin M, Zhang C, Sobczak K, Thornton C A., and Swanson MS. Loss of MBNL Leads to Disruption of Developmentally Regulated Alternative Polyadenylation in RNA Mediated Disease. (2014) Mol. Cell. 56: 311-322
8. Lee KY*, Li M*, Manchanda M, Batra R, Charizanis K, Mohan A, Warren SA, Finn D, Hong H, Ashraf H, Kasahara H, Chamberlain CM, Ranum LPW and Swanson MS. Compound loss of muscleblind-like function in myotonic dystrophy. (2013) EMBO Mol. Med. 5:1887-1900
9. Li M., Liang X., and Rollins J.A. Sclerotinia sclerotiorum gamma-glutamyl transpeptidase (Ss-Ggt1) is required for regulating glutathione accumulation and proper development of sclerotia and compound appressoria. (2012) Mol. Plant Microbe In. 25: 412-420
10. Li M. and Rollins J.A. The development-specific ssp1 and ssp2 genes of Sclerotinia sclerotiorum encode lectins with distinct yet compensatory regulation. (2010) Fungal Genet. Biol. 47: 531-538
11. Li M. and Rollins J.A. The development-specific protein (Ssp1) from Sclerotinia sclerotiorum is encoded by a novel gene expressed exclusively in sclerotium tissues. (2009) Mycologia. 101: 34-43
